Using the PICO Framework in Comparative Effectiveness Research (CER): A Practical Guide for Medical Device Manufacturers and CROs Introduction The PICO framework is one of the most effective methodologies for structuring Comparative Effectiveness Research (CER) in the medical device sector. By clearly defining Population , Inter... CER Clinical Evaluation Report Literature Review MDR Compliance Medical Devices PICO Framework 1 May 2026 0 38 Scientific Methodology